Prediction of gene function: homology searches
Given a nucleotide or DNA sequence, searching the data
base(s) for similar sequences is known as “homology
searches”. The most popular software tool for performing
these searches is called BLAST; therefore biologists often
speak of “BLAST searches”. There are two interesting
How to measure “similarity” of two sequences.
How much similarity constitutes evidence of biologically meaningful homology as opposed to random chance?