Ohio University

Zhu Lab


  1. Zhu S, Donovan EL, Makosa D, Mehta-D'souza P, Jopkiewicz A, Batushansky A, Cortassa D, Simmons AD, Lopes EBP, Kinter M, Griffin TM. Sirt3 promotes chondrogenesis, chondrocyte mitochondrial respiration and the development of high-fat diet-induced osteoarthritis in mice. J Bone Miner Res . 2022 Oct 10. doi: 10.1002/jbmr.4721. Online ahead of print.
  2. Clark BC, Grooms DR, Etheridge T, Wilkinson DJ, Zhu S, Arnold WD, Szewczyk NJ. Editorial: Integrative Physiology of Common Chronic Musculoskeletal Disorders. Front Physiol. 2022 Jul 11;13:971103.
  3. Liu H, Witzigreuter L, Sathiaseelan R, Agbaga MP, Brush RS, Stout MB, Zhu S. Obesity promotes lipid accumulation in mouse cartilage-A potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis. J Orthop Res. 2022 Mar 12. doi: 10.1002/jor.25322. Online ahead of print.
  4. Young JA, Zhu S, List EO, Duran-Ortiz S, Slama Y, Berryman DE. Musculoskeletal Effects of Altered GH Action. Front Physiol. 2022 May 19;13:867921.


  1. Liu H, Rosol TJ, Sathiaseelan R, Mann SN, Stout MB. Zhu S. Cellular carbon stress is a mediator of obesity-associated osteoarthritis development. Osteoarthritis and Cartilage. 2021 May 10, in press.
  2. Zhen G, Guo Q, Li Y, Wu C, Zhu S, Wang R, Guo XE, Kim BC, Huang J, Hu Y, Dan Y, Wan M, Ha T, An S, Cao X.Mechanical stress determines the configuration of TGFβ activation in articular cartilage. Nat Commun. 2021 Mar 17;12(1):1706.
  3. Zhu S, Batushansky A, Jopkiewicz A, Makosa D, Humphries KM, Van Remmen H, and Griffin TM. Sirt5 deficiency causes post-translational protein malonylation and dysregulated metabolism in chondrocytes under obesity conditions. Cartilage. 2021 Feb 11:1947603521993209.


  1. Zhu S, Makosa D, Miller B, Griffin TM. Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis. Connective Tissue Research. 2020 Jan;61(1):34-47.
  2. Zhu S, Chen P, Chen Y, Li M, Chen M, Lu H. 3D-printed extracellular matrix/polyethylene glycol diacrylate hydrogel incorporating the anti-inflammatory phytomolecule honokiol for regeneration of osteochondral defects. Am J Sports Med. 2020 Sep;48(11):2080-2818. PMID: 32762553.
  3. Du X, Chen Y, Zhang Q, Lin J, Yu Y, Pan Z, Sun H, Yuan C, Yu D, Wu H, Zhang X, Dai J, Zhu S, Zhou Y, Ouyang HW. Ezh2 ameliorates osteoarthritis by activating TNFSF13B. J Bone Miner Res. 2020 Jan 7.


  1. Batushansky A, Lopes EBP, Zhu S, Humphries KM, Griffin TM. GC-MS Method for Metabolic Profiling of Mouse Femoral Head Articular Cartilage Reveals Distinct Effects of Tissue Culture and Development. Osteoarthritis and Cartilage. 2019 May 25. pii: S1063-4584(19)31007-6.
  2. Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q, Chen Z, Yang Y, Wan M, Skolasky RL, Cao Y, Wu T, Gao B, Yang M, Gao M, Kuliwaba J, Ni S, Wang L, Wu C, Findlay D, Eltzschig HK, Ouyang HW, Crane J, Zhou FQ, Guan Y, Dong X, Cao X. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest. 2019;129(3):1076-1093. PMID: 30530994. F1000Prime Recommendation.
  3. Chen H, Hu B, Lv X, Zhu S, Zhen G, Wan M, Jain A, Gao B, Chai Y, Yang M, Wang X, Deng R, Wang L, Cao Y, Ni S, Liu S, Yuan W, Chen H, Dong X, Guan Y, Yang H, Cao X. Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. Nature communications. 2019, Jan 14;10(1):181. PMID: 30643142.

    This work was highlighted in Nature Reviews Rheumatology.

  4. Gao B, Deng R, Chai Y, Chen H, Hu B, Wang X, Zhu S, Cao Y, Ni S, Wan M, Yang L, Luo Z, Cao X. Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration. J Clin Invest. 2019,129(6), 2578-2594. PMID: 30946695.
  5. Yang, Long, Tang, Chenqi, Chen, Yangwu, Ruan, Dengfeng, Zhang, Erchen, Yin, Zi, Chen, Xiao, Jiang, Yangzi, Cai, Youzhi, Fei, Yang, Zhu, Shouan, Liu, Huanhuan, Hu, Jiajie, Heng, Boon Chin, Chen, Weishan, Shen, Weiliang, and Ouyang, Hongwei. Pharmacological inhibition of Rac1 activity prevents pathological calcification and enhances tendon regeneration. ACS Biomaterials Science & Engineering. 2019,5,7, 3511-3522. Cover story


  1. Dai J, Yu D, Wang Y, Chen Y, Sun H, Zhang X, Zhu S, Pan Z, Heng BC, Zhang S, Ouyang H. Kdm6b regulates cartilage development and homeostasis through anabolic metabolism. Ann Rheum Dis. 2017, 76(7), 1295-1303. PMID: 28314754. F1000Prime recommendation.
  2. Li YS, Luo W, Zhu SA, Lei GH. T Cells in Osteoarthritis: Alterations and Beyond. Front Immunol. 2017, 8, 356. PMID: 28424692.
  3. Liu H, Yang L, Zhang E, Zhang R, Cai D, Zhu S, Ran J, Bunpetch V, Cai Y, Heng BC, Hu Y, Dai X, Chen X, Ouyang H. Biomimetic tendon extracellular matrix composite gradient scaffold enhances ligament-to-bone junction reconstruction. Acta biomaterialia. 2017, 56, 129-140. PMID: 28502669.
  4. Zhou F, Zhang X, Cai D, Li J, Mu Q, Zhang W, Zhu S, Jiang Y, Shen W, Zhang S, Ouyang HW. Silk fibroin-chondroitin sulfate scaffold with immuno-inhibition property for articular cartilage repair. Acta biomaterialia. 2017, 63, 64-75. PMID: 28890259.


  1. Zhang X, Wu Y, Pan Z, Sun H, Wang J, Yu D, Zhu S, Dai J, Chen Y, Tian N, Heng BC, Coen ND, Xu H, Ouyang H. The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design. Acta Biomaterialia, 2016 Sep 15;42:329-340. PMID: 27345139.


  1. Zhu S, Dai J, Liu H, Cong X, Chen Y, Wu Y, Hu H, Heng BC, Ouyang HW, Zhou Y. Down-Regulation of Rac GTPase-Activating Protein OCRL1 Causes Aberrant Activation of Rac1 in Osteoarthritis Development. Arthritis Rheumatol. 2015, 67(8), 2154-2163. PMID: 25917196.
  2. Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis. 2015, 74(1), 285-293. PMID: 24257023.

    This work was highlighted in Nature Reviews Rheumatology.

    Osteoarthritis: Targeting Rac1 via miroparticlebased drug delivery system protects OA cartilage in vivo. Onuora S. Nature Reviews Rheumatology, 2014,10(1), 1.PMID: 24323070.

  3. Chen P*, Tao J*, Zhu S*, Cai Y, Mao Q, Yu D, Dai J, Ouyang H. Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing. Biomaterials. 2015, Jan;39:114-123. (* co-first author). PMID: 25477178.
  4. Liu H, Zhang C, Zhu S, Lu P, Zhu T, Gong X, Zhang Z, Hu J, Yin Z, Heng BC, Chen X, Ouyang HW. Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway. STEM CELLS, 2015,33(2), 443-455. PMID: 25332192.
  5. Xia Q, Zhu S, Wu Y, Wang J, Cai Y, Chen P, Li J, Heng BC, Ouyang HW, Lu P. Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development. Stem Cells Transl Med. 2015, 4(5), 523-531. PMID: 25824140.


  1. Zhu S, Chen P, Wu Y, Xiong S, Sun H, Xia Q, Shi L, Liu H, Ouyang HW. Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair. Stem Cells Transl Med. 2014, 3(10), 1242-1251. PMID: 25154784.
  2. Chen PF*, Zhu SA*, Wang YY, Mu Q, Wu Y, Xia QQ, Zhang XL, Sun H, Tao JD, Hu H, Lu P, Ouyang HW. ADAMTS-5 inhibitor delivered in hydrogel ameliorates cartilage degeneration. Biomaterials. 2014, Mar;35(9):2827-2836. (* co-first author) PMID: 24424207.
  3. Liu H*, Zhu S*, Zhang C, Lu P, Hu J, Yin Z, Ma Y, Chen X, Ouyang H. Crucial transcription factors in tendon development and differentiation: their potential for tendon regeneration. Cell Tissue Res. 2014, 356(2), 287-298. (* co-first author) PMID: 24705622.
  4. Wu Y, Zhu S, Wu C, Lu P, Hu C, Xiong S, Chang J, Heng BC, Xiao Y, Ouyang HW. A Bi-Lineage Conducive Scaffold for Osteochondral Defect Regeneration. Advanced Functional Materials. 2014, 24(28), 4473-4483.
  5. Shi LB, Cai HX, Chen LK, Wu Y, Zhu SA, Gong XN, Xia YX, Ouyang HW, Zou XH. Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency. Biomaterials. 2014 Feb;35(5):1519-1530. PMID: 24275524.


  1. Zhu S, Liu H, Wu Y, Heng BC, Chen P, Liu H, Ouyang HW. Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy. Arthritis Res Ther. 2013, 15(4), 217. PMID: 23856044.


  1. Gao F, Zhu SA, Xiong SJ. 3-Deoxy-aconitine from the root of Aconitum Carmichaeli Debx. Acta Crystallographica. Section E, Structure Reports Online, 2010 May 15;66(Pt 6):o1342. PMID: 21579431.