Mark Berryman, Ph.D.
Associate Professor of Cell Biology
Department of Biomedical Sciences
237 Life Sciences


Ponnalagu, D., S.G. Rao, J. Farber, W. Xin, A.T. Hussain, K. Shah, S. Tanda,
M. Berryman, J.C. Edwards, H. Singh. Data supporting characterization of CLIC1, CLIC4, CLIC5 and DmCLIC antibodies and localization of CLICs in endoplasmic reticulum of cardiomyocytes. Data in Brief (2016) 7:1038-1044.

Ponnalagu, D., S.G. Rao, J. Farber, W. Xin, A.T. Hussain, K. Shah, S. Tanda, M. Berryman, J.C. Edwards, H. Singh. 2016. Molecular Identity of Cardiac Mitochondrial Chloride Intracellular Channel Proteins. Mitochondrion 27:6-14. PMID: 26777142.

Salles, F.T., L. Andrade, S. Tanda, M. Grati, K. Plona, L.H. Gagnon, K.R. Johnson, B. Kachar, and M.A. Berryman. 2014. CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with Radixin, Taperin, and Myosin VI. Cytoskeleton. 71:61-78. *Our work featured on journal cover* **Top downloaded research article for the journal in 2014 with 721 downloads** (click image to enlarge)

Akbar, H., R. Perveen, X. Shang, M. Berryman, K. Funk, J.F. Johnson, N.N. Tandon, and Y. Zheng. 2011. Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLOS One. 6:e22117.

Abdul-Salam, V.B., J. Wharton, J. Cupitt, M. Berryman, R.J. Edwards, and M.R. Wilkens. 2010. Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension. Circulation. 122:2058-2067.

Wegner, B., A. Al-Momany, S.C. Kulak, K. Kozlowski, M. Obeidat, N. Jahroudi, J. Paes, M. Berryman, and B. Ballermann. 2010. CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity. Am J Physiol Renal Physiol. 298:F1492-1503.

Bradford, E.M., M.L. Miller, V. Prasad, M.L. Nieman, L.R. Gawenis, M. Berryman, J.N. Lorenz, P. Tso, and G.E. Shull. 2010. CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor. Am J Physiol Regul Integr Comp Physiol. 298:R1531-R1542.

Ponsioen, B., L. van Zeiji, M. Langeslag, M. Berryman, D. Littler, K. Jalink, and W. Moolenaar. 2009. Spaciotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA. Mol Biol Cell. 20:4664-4672.

Spiekerkoetter E., C. Guignabert, V. de Jesus Perez, T.P. Alastalo, J.M. Powers, L. Wang, A. Lawrie, N. Ambartsumian, A.M. Schmidt, M. Berryman, R.H. Ashley, and M. Rabinovitch. 2009. S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4.S100A4 and BMP-2 Co-Dependently Induce Vascular Smooth Muscle Cell Migration via pERK and Chloride Intracellular Channel 4 (CLIC4). Circulation Research. 105:639-647.

Tung J.J., O. Hobert, M. Berryman, and J. Kitajewski. 2009. Chloride intracellular channel 4 is involved in endothelial cell proliferation and morphogenesis. Angiogenesis. 12:209-220.

Littler, D.R., S.J. Harrop, L.J. Brown, G.J. Pankhurst, A. Mynott, P. Luciani, R.A. Mandyam, M. Mazzanti, S. Tanda, M.A. Berryman, S.N. Breit, P.M.G. Curmi. 2008. Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC. Proteins. 71:364-378

Gagnon, L.H., C.M. Longo-Guess, M. Berryman, J.B. Shin, K.W. Saylor, H. Yu, P.G. Gillespie, and K.R. Johnson. 2006. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. J. Neuroscience. 26:10188-10198.

Littler, D., N. Assaad, S.J. Harrop, L.J. Brown, G.J. Pankhurst, P. Luciani, M.I. Aguilar, M. Mazzanti, M. Berryman, S.N. Breit, and P.M.G. Curmi.  2005.  Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4.  FEBS J.  272:4996-5007.

Berryman, M., J. Bruno, J. Price, and J.C. Edwards. 2004. CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo. J. Biol. Chem. 279:34794-34801.

Myers, K., P.R. Somanath, M. Berryman, and S. Vijayaraghavan. 2004. Identification of chloride intracellular channel proteins in spermatozoa. FEBS Lett. 566:136-140.

Schaller, S., K. Henriksen, C. Sveigaard, A.-M. Heegaard, N. Helix, M. Stahlhut, M.C. Ovejero, J.V. Johansen, H. Solberg, T.L. Andersen, D. Hougaard, C.B. Shiot, B.H. Sorensen, J. Lichtenberg, P. Christophersen, N.T. Foged, J.-M. Delaisse, M.T. Engsig, M. Berryman, and M.A. Karsdal. 2004. The chloride channel inhibitor NS3736 prevents bone resorption in ovarectomized rats without changing bone formation. J. Bone Mineral Res. 19:1144-1153.

Berryman, M.A., and J.R. Goldenring. 2003. CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells. Cell Motil. Cytoskeleton. 56:159-172. *Supplemental photomicrograph featured on journal cover* (click image to enlarge)

Shanks, R.A., M.C. Larocca, M. Berryman, J.C. Edwards, T. Urushidani, J. Navarre, and J.R. Goldenring. 2002. AKAP350 at the Golgi apparatus: II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. J. Biol. Chem. 277:40973-40980.

Berryman, M., and A. Bretscher. 2001. Immunoblot detection of antigens in immunoprecipitates. Biotechniques. 31:1-2.

Berryman, M., and A. Bretscher. 2000. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol. Biol. Cell. 11:1509-1521.

Bretscher, A., and M. Berryman. 1999. Ezrin, radixin, moesin (ERM proteins). In Guidebook to the Cytoskeletal and Motor Proteins (T. Kreis and R. Vale, eds.), Oxford University Press, New York.

Bretscher, A., and M. Berryman. 1999. Ezrin, radixin, moesin (ERM proteins). In Guidebook to the Extracellular Matrix and Adhesion Proteins (T. Kreis and R. Vale, eds.), Oxford University Press, New York.

Bretscher, A., D. Reczek, and M. Berryman. 1997. Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J. Cell Sci. 110:3011-3018.

Reczek, D., M. Berryman, and A. Bretscher. 1997. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ERM family. J. Cell Biol. 139:169-179. 

Berryman, M., R. Gary, and A. Bretscher. 1995. Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. J. Cell Biol. 131:1231-1242.

Bretscher, A., R. Gary, and M. Berryman. 1995. Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains. Biochemistry. 34:16830-16837.

Berryman, M., and R. Rodewald. 1995. Beta 2-microglobulin co-distributes with the heavy chain of the intestinal IgG-Fc receptor throughout the transepithelial transport pathway of the neonatal rat. J. Cell Sci. 108:2347-2360.

Berryman, M., Z. Franck, and A. Bretscher. 1993. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. J. Cell Sci. 105:1025-1043.

Berryman, M.A., W.R. Porter, R.D. Rodewald, and A.L. Hubbard. 1992. Effects of tannic acid on antigenicity and membrane contrast in ultrastructural immunocytochemistry. J. Histochem. Cytochem. 40:845-857.

Berryman, M.A., and R.D. Rodewald. 1990. An enhanced method for post-embedding immunocytochemical staining which preserves cell membranes. J. Histochem. Cytochem. 38:159-170.

GenBank Submissions

Shanks, R.A., M.C. Larocca, M. Berryman, J.C. Edwards, T. Urushidani, J. Navarre, and J.R. Goldenring. 2001, direct submission. Homo sapiens CLIC5B mRNA; complete coding sequence. Accession number AY032602.

Berryman, M., and A. Bretscher. 1999, direct submission. Homo sapiens CLIC5 mRNA; complete coding sequence. Accession number AF216941.

Reczek, D., M. Berryman, and A. Bretscher. 1998, direct submission. Homo sapiens ezrin-radixin-moesin binding phosphoprotein-50 mRNA; complete coding sequence. Accession number AF015926.

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Heritage College of Osteopathic Medicine
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Last updated: 09/05/2017